Pancreatic Splenic Lobe Organ Culture System: Viability and Amylase Release
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چکیده
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Microtubules and pancreatic amylase release by mouse pancreas in vitro
The effects of vinblastine and colchicine on pancreatic acinar cells were studied by use of in vitro mouse pancreatic fragments. Vinblastine inhibited the release of amylase stimulated by bethanechol, caerulein, or ionophore A23187. Inhibition required preincubation with vinblastine,and maximum inhibition was observed after 90 min. Inhibition was relatively irreversible and could not be overcom...
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Rab3 proteins are believed to play an important role in regulated exocytosis and previous work has demonstrated the presence of Rab3D on pancreatic zymogen granules. To further understand the function of Rab3D in acinar cell exocytosis, adenoviral constructs were prepared encoding hemagglutinin-tagged wild type Rab3D and three mutant forms, N135I and T36N (both deficient in guanine nucleotide b...
متن کاملGalanin Inhibits Rat Pancreatic Amylase Release via Cholinerglc
FLOWE, K. M., K. M. LALLY AND M. W. MULHOLLAND. Galanin inhibits rat pancreatic amylase release via cholinergic suppression. PEPTIDES 13(3) 487-492, 1992.--The effects of galanin on pancreatic exocrine function were examined using rat pancreatic tissues. In anesthetized rats, galanin (40 t~g/kg/h) decreased amylase secretion stimulated by 2-deoxy glucose (5.8 + 0.1 vs. 3.1 _+ 0.1 times basal) a...
متن کاملSelective deficiency of pancreatic amylase.
Two patients with specific pancreatic amylase deficiency are described. The greatly reduced pancreatic amylase activity was not due to an enzymatically inactive amylase molecule but to an almost complete absence of the molecule itself. The findings are of diagnostic importance as they show that low pancreatic amylase activity in serum or duodenal aspirates, or both, does not necessarily represe...
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ژورنال
عنوان ژورنال: Poultry Science
سال: 1993
ISSN: 0032-5791
DOI: 10.3382/ps.0720185